MCWMedical College of Wisconsin · Microbiology & Immunology
The Immune Nexus Lab
Xue-Zhong Yu · Milwaukee, Wisconsin
Research Focus
Dr. Xue-Zhong Yu's lab focuses on understanding the immune responses in the context of graft-versus-host disease (GVHD) and cancer immunotherapy. They investigate the role of cytokines like IL-39 in GVHD and explore how manipulating certain kinases can improve anti-tumor immunity. Additionally, they look into the effects of the gut microbiome and probiotics on GVHD, aiming to enhance patient outcomes after hematopoietic cell transplantation.
GVHDPIM-2IL-39cancer immunotherapygut microbiomeprobioticshematopoietic cell transplantationcytokinesT-cell activation
Research Aims
5AIM 01Evaluate the role of IL-39 in GVHD development
AIM 02Investigate the potential of PIM-2 as a target in cancer immunotherapy
AIM 03Assess the impact of probiotics on GVHD outcomes
AIM 04Determine the functional relevance of intestinal microbiota in immune responses
AIM 05Study the mechanisms of T-cell activation in allogeneic transplantation.
Skills the Lab Values
molecular biology techniquesanimal modelsflow cytometrycell culturegene editing techniquesimmunological assaysbiostatisticshigh-throughput sequencingdata analysis in R
Output against the department
Publications271top 20% of dept.96th of 486
this lab
most publishedleast published
Citations6.2kbottom 46% of dept.264th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.