Stanford University · Biomedical EngineeringTumor Suppression and Therapeutics Lab
Laura D Attardi · Stanford, California
Research Focus
Dr. Laura D. Attardi's lab focuses on understanding how the p53 gene helps suppress cancer. By studying its pathways and interactions, the lab aims to identify potential new treatments for various cancers like lung adenocarcinoma and hepatocellular carcinoma. The research uses advanced techniques like CRISPR and single-cell sequencing to gain insights into cancer biology and improve therapeutic strategies.
p53tumor suppressionlung adenocarcinomahepatocellular carcinomaalternative splicingCRISPRsingle-cell sequencingproteomicscancer therapy
Research Aims
5AIM 01Identify p53-dependent splicing and proteome changes related to tumor suppression.
AIM 02Investigate genes that cooperate with p53's target gene Zmat3 in cancer suppression.
AIM 03Explore p53's role in lung regeneration and its effect on cancer cell differentiation.
AIM 04Understand how p53 status influences cancer evolution in mouse models.
AIM 05Analyze interactions between cancer cells and the tumor microenvironment.
Skills the Lab Values
CRISPR/Cas9RNA sequencingalternative splicing analysismouse modelsproteomicscell culturesingle-cell RNA sequencingin vivo assaysflow cytometry
Output against the department
Publications275top 35% of dept.208th of 595
this lab
most publishedleast published
Citations24ktop 14% of dept.82nd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.