University of Pennsylvania · GeneticsEpstein Audiology Lab
Douglas J Epstein · Philadelphia, Pennsylvania
Research Focus
Douglas Epstein's research lab focuses on understanding the genetic causes of adult-onset hearing loss, specifically investigating mutations in the Zfp719 gene. By conducting studies on genetically altered mice and utilizing advanced genomic techniques, the lab aims to identify how these mutations affect inner ear functions and contribute to hearing loss. The research not only seeks to elucidate the biological mechanisms behind this condition but also hopes to pave the way for new therapies and screening methods for high-risk individuals.
hearing lossgenetic mutationsZfp719inner earauditory functiongene therapymolecular mechanismscochlear developmentsenescencesymptomatic treatment
Research Aims
5AIM 01Identify genetic mutations associated with adult-onset hearing loss.
AIM 02Investigate the cellular mechanisms affected by Zfp719 mutations.
AIM 03Examine the role of heterochromatin in gene regulation related to hearing.
AIM 04Develop potential preventative and restorative treatments for hearing loss.
AIM 05Enhance screening methods for high-risk individuals to facilitate early intervention.
Skills the Lab Values
genetic sequencingmouse modelsfunctional assayscell culture techniquesgenome editingphenotypingbiobankingmolecular cloningPCRbioinformatics
Output against the department
Publications70bottom 17% of dept.216th of 259
this lab
most publishedleast published
Citations8.6kbottom 46% of dept.141st of 259
this lab
most citedleast cited
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