Massachusetts Institute of Technology · BiologyYilmaz Lysosome Lab
Omer Yilmaz · Cambridge, Massachusetts
Research Focus
Omer Yilmaz's lab studies the role of lysosomes in intestinal stem cells and cancer, particularly how fasting influences these processes. By investigating how lysosomes help maintain stem cells and contribute to the development of tumors, the lab hopes to uncover new therapies for improving health through better understanding of cellular and organismal physiology. Their work combines genetics, biochemistry, and cutting-edge techniques to explore the underlying mechanisms involved in stem cell function and tumor progression.
lysosomesfastingintestinal stem cellstumorigenesisautophagymetabolomicsgenetic regulationcellular homeostasisbiochemical techniquescancer research
Research Aims
3AIM 01Characterize the role of TFE3 and TFEB in maintaining intestinal stem cells during fasting.
AIM 02Investigate how lysosomes support intestinal stem cells through transcriptomic and proteomic analyses.
AIM 03Explore the impact of lysosomes on intestinal tumorigenesis and potential synergy with chemotherapy.
Skills the Lab Values
PCRcell culturemouse modelslysosomal purification (LysoIP)metabolomic profilingproteomic profilingmolecular cloningtranscriptional analysisgenetic knockout techniqueschemotherapy sensitization testing
Output against the department
Publications211top 31% of dept.317th of 1,033
this lab
most publishedleast published
Citations302bottom 1% of dept.1,019th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.