Yale University · PhysiologyThe Cyst Dynamics Lab
Michael J. Caplan · New Haven, Connecticut
Research Focus
Dr. Michael J. Caplan's research focuses on understanding the mechanisms behind Autosomal Dominant Polycystic Kidney Disease (ADPKD), a genetic disorder that leads to kidney dysfunction. His lab investigates the role of a specific protein fragment from polycystin-1 in preventing cyst formation and maintaining kidney health. By exploring how this fragment interacts with cellular structures and metabolism, the lab aims to identify new therapeutic targets for treating ADPKD.
ADPKDpolycystin-1mitochondriacyst formationrenal functionprotein cleavagemolecular interactionsmouse models
Research Aims
3AIM 01Investigate how polycystin-1 C-terminal fragments affect mitochondrial function.
AIM 02Evaluate the potential of C-terminal fragment P200 in reversing cystic disease in mouse models.
AIM 03Determine the in vivo production processes of PC1 cleavage fragments.
Skills the Lab Values
molecular cloningtransgenic mouse modelsimmunoblottingcell culturehistologygenotypingRNA extractionfluorescence microscopymetabolic assays
Output against the department
Publications324top 14% of dept.41st of 286
this lab
most publishedleast published
Citations14ktop 22% of dept.62nd of 286
this lab
most citedleast cited
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