University of Michigan-Ann Arbor · EngineeringThurber Gene Therapy Lab
Greg Thurber · Ann Arbor, Michigan
Research Focus
Dr. Greg Thurber's lab focuses on developing innovative methods to deliver genetic therapies specifically to neurons in the brain. They create unique antibody-based systems that can cross the blood-brain barrier non-invasively and modulate gene expression, which is crucial for understanding brain function and treating neurological disorders. Their work aims to address challenges in gene therapy, particularly for conditions like Dravet syndrome.
gene expressionblood-brain barrierneuron targetingbispecific antibodiesantisense oligonucleotidesDravet syndromeneurosciencegene therapy
Research Aims
4AIM 01Develop a bispecific antibody system to deliver antisense oligonucleotides to neurons.
AIM 02Evaluate the effectiveness of neuron-targeted antibodies in improving gene expression in Dravet syndrome models.
AIM 03Optimize the design of bispecific antibodies for targeting different neuronal surface proteins.
AIM 04Assess the specificity and efficacy of gene silencing using second-generation bispecific antibodies.
Skills the Lab Values
antibody designgene editing techniquesin vivo mouse modelsPCRfluorescent in situ hybridizationsingle-cell RNA sequencingimmunological methodsbioconjugation techniqueselectrophysiology
Output against the department
Publications174bottom 44% of dept.157th of 278
this lab
most publishedleast published
Citations4.6kbottom 36% of dept.178th of 278
this lab
most citedleast cited
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