Yale University · Biomedical EngineeringCancer Immunology and RNA Dynamics Lab
Luisa Escobar Hoyos · New Haven, Connecticut
Research Focus
Dr. Luisa Escobar Hoyos's lab at Yale University focuses on uncovering new ways to enhance the immune response against cancers, particularly through T-cell activation. Research efforts aim to understand how RNA splicing defects influence T-cell function and how targeting these defects can improve cancer immunotherapy. The lab also studies the implications of specific mutations in pancreatic cancer, aiming to develop therapies that correct these mutations to better combat aggressive tumor growth.
RNA splicingT-cell immunotherapypancreatic cancercancer vaccinesmutant splicing factorsimmune evasiontumor antigensanti-bacterial immunitycheckpoint inhibitorstumor microenvironment
Research Aims
5AIM 01Understand the mechanisms by which altered RNA splicing affects T-cell anti-tumor immunity.
AIM 02Investigate the role of mutant splicing factors in the development of pancreatic cancer.
AIM 03Develop methods to correct RNA splicing defects in T-cells and assess their impact on therapy efficacy.
AIM 04Test the effectiveness of new cancer vaccines targeting virulence factors in tumor cells.
AIM 05Explore how anti-bacterial memory in T-cells can enhance their response against tumors.
Skills the Lab Values
RNA sequencingCRISPRmouse modelscell cultureflow cytometryWestern blotbioinformaticsprotein analysistumor profiling
Output against the department
Publications121bottom 25% of dept.448th of 595
this lab
most publishedleast published
Citations1.6kbottom 11% of dept.532nd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.