Columbia University in the City of New York · NeuroscienceThe SORL1 Initiative
Scott A Small · New York, New York
Research Focus
Scott A Small's lab at Columbia University Health Sciences focuses on understanding the role of the SORL1 gene in Alzheimer's disease. They investigate how different variants of this gene contribute to the disease's development and progression, particularly through its interaction with the retromer trafficking complex. The lab aims to decipher the mechanisms behind these variants to inform potential therapies for patients with Alzheimer's, especially those with specific genetic mutations.
Alzheimer's DiseaseSORL1genetic variantsretromerpathophysiologytherapeutic interventionsmissense mutationsloss-of-function variants
Research Aims
5AIM 01Identify pathogenic SORL1 variants associated with Alzheimer's disease.
AIM 02Investigate the interaction of SORL1 with the retromer trafficking complex.
AIM 03Clarify the mechanisms by which SORL1 variants lead to Alzheimer’s pathology.
AIM 04Develop strategies for therapeutic intervention targeting SORL1-related pathways.
AIM 05Explore the broader implications of SORL1 disruptions on late-onset Alzheimer's disease.
Skills the Lab Values
genetic analysisprotein interaction studiescell culturebiochemical assaysbioinformaticsstructural biology techniquesclinical studiesanimal modelsdata interpretation
Output against the department
Publications155top 48% of dept.324th of 671
this lab
most publishedleast published
Citations15ktop 26% of dept.177th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.