University of Southern California · BiochemistryLi Epigenetics Lab
Sheng Li · Los Angeles, California
Research Focus
Dr. Sheng Li's lab at the University of Southern California focuses on exploring how changes in the epigenome influence cell behavior, differentiation, and disease. By using advanced computational tools and next-generation sequencing data, the lab aims to uncover how epigenetic modifications regulate gene expression across the entire mouse genome. The research combines biochemistry and computational biology to enhance our understanding of cellular plasticity and heterogeneity, with the goal of creating valuable resources for the scientific community.
epigeneticsgene regulationtranscription factorscomputational biologyDNA methylationcell differentiationchromatin remodelinggenomic heterogeneitynext-generation sequencing
Research Aims
4AIM 01Develop computational tools to analyze epigenetic patterns in the complete mouse genome.
AIM 02Investigate allele-specific epigenetic heterogeneity in genomic regions.
AIM 03Assess the impact of transcription factor motifs on epigenetic regulation.
AIM 04Explore the functions of epigenetic regulators on DNA and histone methylation.
Skills the Lab Values
computational analysisDNA sequencingbioinformaticschromatin immunoprecipitationgenome annotationdata visualizationRNA sequencingmolecular cloningcell culture
Output against the department
Publications455top 10% of dept.41st of 402
this lab
most publishedleast published
Citations4.4kbottom 24% of dept.304th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.