University of Illinois Chicago · Microbiology & ImmunologyAntibody Diversity and Immunity Lab
Amy L Kenter · Chicago, Illinois
Research Focus
Dr. Amy Kenter's lab studies how antibodies are formed by exploring the genetic rearrangements that create a diverse set of these crucial immune molecules. By mapping the three-dimensional structure of antibodies' genetic material, the lab aims to understand the factors that influence the selection and efficient use of these antibodies during immune responses. This research contributes to improving vaccine development by enhancing our knowledge of immune system function.
antibody diversityV(D)J recombinationgenetic rearrangementB-cell developmentchromatin structureenhancersimmune responsevaccine development
Research Aims
5AIM 01Characterize novel enhancers involved in antibody gene usage during B-cell development.
AIM 02Define the three-dimensional architecture of the immunoglobulin heavy chain locus.
AIM 03Investigate the role of looping interactions in V(D)J recombination.
AIM 04Explore the relationship between enhancer regions and active transcription marks.
AIM 05Improve understanding of antibody repertoire selection relevant to vaccine development.
Skills the Lab Values
chromosome conformation captureknockout mouse modelsconfocal microscopycell line developmentDNA analysisgenome editingH3K27Ac markingchromatin loop mapping3D genomic organization
Output against the department
Publications100bottom 35% of dept.314th of 486
this lab
most publishedleast published
Citations1.8kbottom 11% of dept.432nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.