University of Texas Southwestern Medical Center · NeuroscienceNeuromuscular Junction Research Lab
Weichun Lin · Dallas, Texas
Research Focus
Dr. Weichun Lin's lab at UT Southwestern focuses on understanding how motor neurons develop and connect with skeletal muscles at the neuromuscular junction (NMJ). By studying the signals between muscles and nerves, the lab aims to discover the mechanisms that help maintain motor neurons and form healthy synapses. This research is crucial for developing effective treatments for neuromuscular diseases, especially amyotrophic lateral sclerosis (ALS).
motor neuronsneuromuscular junctionsynapse formationALSgene deletionmuscle signalingcholinergic synapsesneurodegenerative diseases
Research Aims
5AIM 01Define the mechanisms of motor neuron development.
AIM 02Investigate the formation and maturation of the neuromuscular junction.
AIM 03Identify muscle-derived signals that promote motor neuron survival.
AIM 04Explore genetic factors that impact neuromuscular junction health.
AIM 05Develop therapeutic strategies for neurodegenerative diseases.
Skills the Lab Values
gene editingmouse modelsimmunohistochemistryprotein analysiscell culturemolecular cloningWestern blottingRT-PCRimaginggenetic transfection
Output against the department
Publications63bottom 16% of dept.563rd of 671
this lab
most publishedleast published
Citations3.3kbottom 25% of dept.505th of 671
this lab
most citedleast cited
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