Stanford University · Biomedical EngineeringThe T Cell Imaging Initiative
Michelle Louise James · Stanford, California
Research Focus
Dr. Michelle Louise James's lab at Stanford University focuses on improving cancer immunotherapy, particularly through the development of imaging techniques that can track the activity of specialized T cells used in therapies like CAR T cell treatment. By creating advanced imaging agents, the lab aims to provide doctors with new tools to monitor and optimize these therapies for better patient outcomes. Their work seeks to enhance our understanding of how T cells behave in the body and improve treatment effectiveness for cancer patients.
immunoPETCAR T cell therapyT cell activationclinical translationcancer immunotherapyimaging agentsradiolabelingimmunotherapy monitoringbiomarkersPET radiotracers
Research Aims
4AIM 01Develop human-specific radiotracers for OX40 and ICOS to visualize activated T cells.
AIM 02Optimize the radiolabeling process and assess the stability of new radiotracers.
AIM 03Investigate the biological effects and in vivo binding of the radiotracers to activated human T cells.
AIM 04Evaluate safety and specificity of imaging agents for CAR T cell application.
Skills the Lab Values
radiolabeling techniquesimmunohistochemistrycell cultureanimal modelsmolecular imagingantibody engineeringflow cytometryin vivo imagingspectrometrybiostatistics
Output against the department
Publications157bottom 34% of dept.391st of 595
this lab
most publishedleast published
Citations5.7kbottom 44% of dept.331st of 595
this lab
most citedleast cited
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