Dartmouth College · BiochemistryPrion Biology and Therapeutics Lab
Surachai Supattapone · Hanover, New Hampshire
Research Focus
Dr. Surachai Supattapone's lab at Dartmouth College focuses on understanding prion diseases, which are caused by misfolded proteins that lead to neurodegenerative disorders such as Creutzfeldt-Jakob disease. The lab uses advanced genetic screening techniques to map the molecular pathways that control the metabolism of prion proteins, aiming to identify potential new targets for drug therapy. Their research not only enhances our knowledge of prion biology but also contributes to the development of therapeutic strategies for these fatal brain diseases.
prion diseasesCreutzfeldt-Jakob diseaseChronic Wasting Diseaseprion proteinCRISPRneurodegenerationprotein metabolismgenetic screeningcell biology
Research Aims
4AIM 01Map the molecular pathways that control prion protein metabolism.
AIM 02Identify the genes involved in the biosynthesis and degradation of prions.
AIM 03Discover the rate-limiting steps in prion formation and clearance.
AIM 04Develop new strategies for therapeutic targeting of prion diseases.
Skills the Lab Values
fluorescence-activated cell sorting (FACS)CRISPR/Cas9 gene editingcell culture techniquesgenome library screeningprotein purificationnext generation sequencinginduced pluripotent stem cells (iPSCs)cellular imagingmolecular cloning
Output against the department
Publications124bottom 34% of dept.263rd of 402
this lab
most publishedleast published
Citations8.9kbottom 46% of dept.217th of 402
this lab
most citedleast cited
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