The University of Texas Health Science Center at San Antonio · BiochemistrySARS-CoV-2 RNA Modification Lab
Yogesh K Gupta · San Antonio, Texas
Research Focus
Dr. Yogesh K Gupta's lab focuses on understanding how the SARS-CoV-2 virus modifies its RNA to evade the human immune system. By studying a specific protein complex that adds a chemical cap to the viral RNA, the lab aims to uncover mechanisms that can help develop therapies for COVID-19 and potentially other viral infections. The research combines structural biology, molecular tools, and drug development to create innovative antiviral treatments.
SARS-CoV-2RNA modificationviral replicationantiviral drug developmentimmune evasionX-ray crystallographymolecular toolsCOVID-19 therapeuticsbiochemical studiesreverse genetics
Research Aims
5AIM 01Resolve the structures of nsp16/nsp10 proteins using X-ray crystallography.
AIM 02Develop methods to study RNA methylation during SARS-CoV-2 infection.
AIM 03Investigate the effects of nsp16 mutations on viral replication.
AIM 04Identify small molecules that inhibit SARS-CoV-2 and related viruses.
AIM 05Combine genomic approaches to inform new antiviral treatments.
Skills the Lab Values
X-ray crystallographyRNA sequencingmolecular cloningcell culturebiochemical assaysbiophysical studiesdrug repurposing techniquesmouse modelsstructural biologymolecular biology techniques
Output against the department
Publications104bottom 26% of dept.298th of 402
this lab
most publishedleast published
Citations2.4kbottom 9% of dept.364th of 402
this lab
most citedleast cited
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