North Carolina State University at Raleigh · BiologyOsteoarthritis Pain Research Lab
Santosh K. Mishra · Raleigh, North Carolina
Research Focus
Dr. Santosh K. Mishra's lab focuses on understanding the mechanisms behind osteoarthritis (OA) pain, a condition that affects millions of adults. The lab investigates how the signaling pathways of artemin and its receptor relate to the pain experienced in OA, aiming to uncover new therapeutic targets. This research could pave the way for innovative and safer treatments for those suffering from chronic OA pain.
osteoarthritispain signalingarteminGFR3therapeutic targetspain managementchronic paintransient receptor potential channelslarge animal models
Research Aims
4AIM 01Investigate the expression of artemin (ARTN) in osteoarthritis and its role in pain.
AIM 02Examine the relationship between ARTN/GFR3 signaling and OA pain in different disease stages.
AIM 03Analyze how RET-dependent ARTN/GFR3 signaling influences TRP channel expression and activation.
AIM 04Validate the involvement of these signaling pathways in naturally occurring osteoarthritis in dogs.
Skills the Lab Values
animal handlingquantitative reverse transcriptase PCR (qRT-PCR)behavioral assaysin vivo modelsmolecular biology techniquesprotein analysisimmunohistochemistrydata analysis using softwarebiostatistics
Output against the department
Publications71bottom 20% of dept.829th of 1,033
this lab
most publishedleast published
Citations3.2kbottom 24% of dept.783rd of 1,033
this lab
most citedleast cited
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