Columbia University in the City of New York · BiologyCellular Signaling Dynamics Lab
Iva S Greenwald · New York, New York
Research Focus
Iva S. Greenwald's lab at Columbia University focuses on understanding how cells communicate and decide their roles during development using the model organism C. elegans, a tiny roundworm. By investigating the Notch signaling pathway and its interactions with other key signaling systems, the lab aims to uncover fundamental mechanisms that can impact human health, particularly in relation to cancer and congenital disorders. The research combines traditional genetic techniques with modern genome engineering tools, enabling detailed study of cellular processes and signaling dynamics.
Notch signalingC. eleganscell fate determinationgenome engineeringdevelopmental biologycell communicationstochastic processesaberrant signalingorgan development
Research Aims
5AIM 01Investigate the mechanisms by which ligands activate Notch signaling.
AIM 02Explore the process of lateral inhibition during cell fate decisions.
AIM 03Examine how different organ development is coordinated through conserved signaling pathways.
AIM 04Understand the impact of stochastic differences in cell fate outcomes.
AIM 05Utilize new biosensors and imaging techniques to study cellular communication.
Skills the Lab Values
CRISPR/Cas9 genome editinggenetic analysislong-term imagingcell culture techniquestranscriptome profilingfluorescence microscopysignal transduction assaysdata analysis using Pythondevelopmental assays
Output against the department
Publications148top 46% of dept.473rd of 1,033
this lab
most publishedleast published
Citations14ktop 27% of dept.284th of 1,033
this lab
most citedleast cited
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