University of Washington-Seattle Campus · PharmacologyCortisol Regulation and Precision Medicine Lab
John D Scott · Seattle, Washington
Research Focus
Dr. John D. Scott's lab at the University of Washington studies how specific proteins can control the release of cortisol, the stress hormone, from our adrenal glands. They focus on a condition called Cushing's syndrome, which causes the body to produce too much cortisol, leading to serious health issues. The lab's goal is to understand the mutations in a protein called PKA that contribute to this syndrome and to develop more effective treatments using precision medicine.
PKA signalingCushing's syndromehormonal regulationprotein kinaseprecision medicine
Research Aims
3AIM 01Investigate the frequency and impact of PKAc mutations in Cushing's syndrome patients.
AIM 02Examine how specific PKA mutants affect cortisol release and signaling pathways.
AIM 03Test targeted drug strategies to inhibit cortisol hypersecretion.
Skills the Lab Values
cell cultureCRISPRmolecular cloningprotein purificationanimal modelsbiochemical assays
Output against the department
Publications440top 13% of dept.59th of 462
this lab
most publishedleast published
Citations36ktop 7% of dept.32nd of 462
this lab
most citedleast cited
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