Pennsylvania State University-Main Campus · BiochemistryBai Chromatin Lab
Lu Bai · University Park, Pennsylvania
Research Focus
Dr. Lu Bai's lab at Penn State University focuses on understanding how chromatin structure influences gene regulation. The lab investigates the mechanisms that lead to chromatin accessibility and the organization of chromosomes within the nucleus. This research is significant for unraveling the complexities of gene expression, particularly in relation to human diseases.
chromatin accessibilitygene regulationchromosome organizationnucleosome depletionpioneer factorstranscriptional regulation3D genome dynamicscancer biologycell biologytherapeutic targeting
Research Aims
4AIM 01Identify pioneer factors responsible for chromatin accessibility in human cells.
AIM 02Investigate the mechanism of binding cooperativity among pioneer factors.
AIM 03Understanding the interactions between pioneer factors and chromatin remodelers.
AIM 04Explore the role of chromosome structure in gene regulation and nuclear processes.
Skills the Lab Values
chromatin immunoprecipitation (ChIP)3D chromosome conformation capture (3C)imaging techniquesnucleosome assemblysynthetic oligonucleotide designfluorescence microscopycell cultureWestern blottingRNA sequencingdata analysis with Python
Output against the department
Publications101bottom 25% of dept.301st of 402
this lab
most publishedleast published
Citations3.5kbottom 17% of dept.332nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.