University of Kansas · PharmacologySubramanian Lab
Jaichandar Subramanian · Lawrence, Kansas
Research Focus
Dr. Jaichandar Subramanian's research lab focuses on understanding Alzheimer's disease, particularly how changes in neuronal activity and synaptic function relate to mitochondrial health. By studying mouse models of the disease, the lab aims to uncover how these factors interact across different ages and brain regions. Ultimately, the goal is to find ways to improve cognitive function by restoring normal brain activity and synapse structure.
Alzheimer's DiseaseNeuronal ActivitySynaptic AbnormalitiesMitochondrial HealthCognitive DeclineNeural PlasticityMouse ModelsAmyloidosisPharmacological Manipulations
Research Aims
5AIM 01Investigate the relationship between synaptic abnormalities and neuronal activity in Alzheimer's disease.
AIM 02Explore age-related differences in mitochondrial function across brain regions.
AIM 03Test the effectiveness of Cyclophilin D targeting on mitochondrial health.
AIM 04Enhance neural plasticity through pharmacological interventions.
AIM 05Assess the interplay between amyloidosis and synaptic function.
Skills the Lab Values
Mouse modelsIn vivo experimentationEx vivo analysisPharmacological testingTwo-photon microscopyBiochemical assaysCalcium imagingGenetic manipulationSynaptic structure assessment
Output against the department
Publications31bottom 3% of dept.449th of 462
this lab
most publishedleast published
Citations678bottom 2% of dept.451st of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.