University of Kentucky · BiologyLung Cancer Metastasis Research Lab
Houfu Guo · Lexington, Kentucky
Research Focus
Dr. Houfu Guo's lab at the University of Kentucky focuses on understanding how certain enzymes modify collagen and contribute to the spread of lung cancer. Specifically, they are investigating the role of a newly identified enzyme, lysyl hydroxylase 2b (LH2b), in promoting cancer metastasis. By studying its structure and function, the lab aims to reveal new therapeutic targets for treating lung cancer and potentially other cancer types as well.
lung cancermetastasiscollagenglucosyltransferaseenzyme regulationtherapeutic developmentcancer progressionprotein structurecollagen-modifying enzymes
Research Aims
4AIM 01Investigate the role of LH2b in lung cancer metastasis.
AIM 02Determine how LH2b modifies collagen in the tumor microenvironment.
AIM 03Explore the structural basis of LH2b's enzymatic activity.
AIM 04Assess the prognostic value of LH2b expression in cancer.
Skills the Lab Values
protein purificationenzymatic assaysstructural biologymolecular cloningPCRcell cultureWestern blotRNA sequencingbioinformaticsmicroscopy
Output against the department
Publications62bottom 16% of dept.866th of 1,033
this lab
most publishedleast published
Citations1.4kbottom 8% of dept.949th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.