Washington University in St Louis · Biomedical EngineeringBK Channel and Neurological Disorders Lab
Jianmin Cui · Saint Louis, Missouri
Research Focus
Dr. Jianmin Cui's lab at Washington University focuses on understanding how specific mutations in the BK potassium channel affect brain activity and contribute to neurological disorders like epilepsy and movement disorders. By studying these mutations, the lab aims to develop targeted treatments that can better address the symptoms associated with these conditions. The research combines molecular biology, electrophysiology, and drug design to improve diagnosis and treatment options for patients with these genetic variants.
BK ChannelopathyEpilepsyNeurodevelopmental DisordersMovement DisordersPrecision MedicineMolecular GatingNeuronal ActivityDrug Design
Research Aims
3AIM 01Identify and compare the molecular gating mechanisms of KCNMA1 variants.
AIM 02Analyze the impact of KCNMA1 mutations on neuronal activity.
AIM 03Develop and test variant-specific drug inhibitors to mitigate neurological symptoms.
Skills the Lab Values
ElectrophysiologyMolecular AnalysisMouse ModelsGenotypingDrug ScreeningCell CultureBiophysical ModelingBehavioral AssessmentStatistical Analysis
Output against the department
Publications212bottom 49% of dept.302nd of 595
this lab
most publishedleast published
Citations8.1ktop 42% of dept.250th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.