University of Kansas · BiochemistryTikhanovich Lab
Irina Tikhanovich · Lawrence, Kansas
Research Focus
Dr. Irina Tikhanovich's lab focuses on understanding the mechanisms behind alcohol-associated liver disease (ALD). The research aims to investigate how certain liver cells signal to aid in the resolution of fibrosis after alcohol withdrawal. By studying the role of the Acute Phase Response, the lab hopes to develop new therapeutic strategies to improve liver recovery among patients with ALD.
alcohol-associated liver diseasefibrosis resolutionacute phase responsehepatocyte signalingliver macrophagesepigeneticscollagen degradation
Research Aims
3AIM 01Define how APR signaling remodels the fibrolytic liver niche.
AIM 02Determine the mechanism of C/EBP-dependent APR gene expression.
AIM 03Assess the role of HDL in APR-induced niche remodeling.
Skills the Lab Values
mouse modelsRNA sequencingcell culturein vivo experimentsWestern blotspatial transcriptomicsflow cytometrymolecular cloningprotein expression analysis
Output against the department
Publications40bottom 4% of dept.384th of 402
this lab
most publishedleast published
Citations1.1kbottom 3% of dept.390th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.