Case Western Reserve University · BiochemistryNerve Invasion and Metastasis Lab
Susann M Brady-Kalnay · Cleveland, Ohio
Research Focus
Dr. Susann Brady-Kalnay's lab focuses on understanding how cancer cells invade and metastasize along nerves. By investigating a specific biomarker found in cancer that is linked to this nerve growth, they are developing nanoparticles that can be used for both imaging and treatment of metastatic breast cancer. This research aims to improve early detection and provide better therapeutic outcomes through targeted therapies and enhanced radiation treatment.
breast cancerneural invasionmetastasistheranostic agentsgold nanoparticles
Research Aims
5AIM 01Identify the role of the PTP biomarker in neural invasion of breast cancer cells.
AIM 02Develop gold nanoparticles that target and treat metastatic breast cancer.
AIM 03Enhance the imaging and therapeutic efficacy of radiation therapy.
AIM 04Investigate the mechanisms of cancer cell migration along nerves.
AIM 05Utilize patient-derived models to test treatment strategies.
Skills the Lab Values
cell culture3D imagingnanoparticle synthesisanimal modelsfluorescent imagingradiation therapy techniquesbiomarker analysisdata analysis with Pythonproteolysis assays
Output against the department
Publications107bottom 27% of dept.295th of 402
this lab
most publishedleast published
Citations4.0kbottom 22% of dept.315th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.