University of Pittsburgh-Pittsburgh Campus · ChemistryCancer Therapy Innovations Lab
Alexander Deiters · Pittsburgh, Pennsylvania
Research Focus
Dr. Alexander Deiters' lab at the University of Pittsburgh focuses on enhancing cancer therapy through innovative technologies. The research centers on developing small molecule adaptors that improve the efficacy of Chimeric Antigen Receptor (CAR) T cell therapies, by enabling them to target multiple types of cancer cells more precisely and effectively. This work seeks to make cancer treatments more accessible and improve patient outcomes for a variety of diseases.
CAR T cell therapysmall molecule adaptorstargeted cancer therapysolid tumorsuniversal CARimmunologydrug design
Research Aims
5AIM 01Develop small molecule adaptors to target multiple antigens for CAR therapy.
AIM 02Enhance the specificity of CAR targeting through chemical switches.
AIM 03Expand targeting options to neoepitopes on tumor cells.
AIM 04Utilize covalent modification for improved CAR efficacy.
AIM 05Make CAR therapy more accessible through cost-effective solutions.
Skills the Lab Values
chemical synthesiscell cultureimmunology techniquesflow cytometrycellular assaysprotein modificationmicroscopybioinformaticssynthetic biology
Output against the department
Publications306top 37% of dept.79th of 216
this lab
most publishedleast published
Citations16ktop 31% of dept.66th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.