Wright State University-Main Campus · BiochemistryKadakia Lab
Madhavi P Kadakia · Dayton, Ohio
Research Focus
Dr. Madhavi P. Kadakia's lab focuses on understanding how certain proteins, specifically Np63 and TIP60, influence the behavior of squamous cell carcinoma (SCC), particularly in their ability to resist chemotherapy treatments like cisplatin. The research aims to uncover why SCC tumors often become resistant to such treatments and to explore new strategies that could help overcome this challenge. Their work is significant as it seeks to find better ways to treat head and neck cancers, ultimately improving patient outcomes.
squamous cell carcinomacisplatinTIP60Np63chemoresistancecancer therapyapoptosisheat shock proteinstherapeutic targetsDNA damage response
Research Aims
3AIM 01Investigate how TIP60 affects the stability and function of Np63.
AIM 02Determine the role of Np63 acetylation in DNA damage response and apoptosis.
AIM 03Evaluate the effectiveness of TIP60 inhibitors in overcoming cisplatin resistance in SCC.
Skills the Lab Values
cell culturemouse modelsWestern blotRNA sequencingChIP-seqapoptosis assaysin vitro analysesxenograft modelsdrug efficacy testingmolecular cloning
Output against the department
Publications85bottom 18% of dept.328th of 402
this lab
most publishedleast published
Citations1.8kbottom 6% of dept.376th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.