UMCUniversity of Massachusetts Chan Medical School · Biology
The Epitranscriptome Project
Richard I. Gregory · Worcester, Massachusetts
Research Focus
Dr. Richard Gregory's lab focuses on understanding the role of RNA modifications in cancer, particularly how these changes can influence gene expression and cancer progression. By studying tRNA and mRNA modifications, the lab aims to uncover novel therapeutic targets for cancer treatment. Their research involves advanced techniques such as RNA mass spectrometry and high-throughput screening to identify potential drugs to combat cancer.
RNA modificationscancertRNAepitranscriptomemRNA methylationmelanomatherapeutic targetstranslational remodeling
Research Aims
5AIM 01Investigate the role of tRNA modification in cancer progression.
AIM 02Explore mRNA methylation as a therapeutic target in cancer.
AIM 03Utilize innovative methodologies to study RNA modifications in melanoma.
AIM 04Perform functional screenings of tRNA genes involved in cancer stress responses.
AIM 05Identify small molecules that inhibit mRNA methyltransferases for cancer treatment.
Skills the Lab Values
RNA mass spectrometryRibo-seqhigh-throughput screeningcell culturemouse modelsproteomicssequencingbioinformaticsdata analysis
Output against the department
Publications137bottom 49% of dept.522nd of 1,033
this lab
most publishedleast published
Citations32ktop 10% of dept.103rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.