University of Minnesota-Twin Cities · PharmacologyNguyen Lab
Dang Hai Nguyen · Minneapolis, Minnesota
Research Focus
The Nguyen lab at the University of Minnesota focuses on understanding myelodysplastic syndromes (MDS), which are disorders that affect blood cell production and lead to serious health issues. Their research explores how specific mutations related to RNA splicing can lead to genomic instability in these conditions, and they are investigating the role of PARP1—a protein involved in DNA repair—through the lens of R-loops, a type of genetic material interplay. The ultimate goal is to develop targeted therapies using existing FDA-approved PARP inhibitors for patients with specific genetic mutations related to MDS.
myelodysplastic syndromesRNA splicingPARP1genomic instabilityR-loopstargeted therapyhematological disorders
Research Aims
3AIM 01Elucidate mechanisms by which PARP1 is activated by R-loops.
AIM 02Identify global PARP1 substrates and R-loop distribution in U2AF1-mutant cells.
AIM 03Evaluate the effect of PARP inhibitor olaparib on MDS-associated splicing mutant cells in vitro and in vivo.
Skills the Lab Values
cell cultureRNA sequencinggenomicsproteomicsmouse modelsDNA damage assaysWestern blotPCRdrug testingbioinformatics
Output against the department
Publications201top 44% of dept.203rd of 462
this lab
most publishedleast published
Citations25ktop 13% of dept.59th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.