UWMUniversity of Wisconsin-Madison · Biochemistry
Beta Cell Stress Response Unit
Feyza Engin · Madison, Wisconsin
Research Focus
Dr. Feyza Engin's lab focuses on understanding how stress affects insulin-producing beta cells in Type 1 diabetes (T1D). They explore the different responses beta cells exhibit under stress, which can either lead to disease progression or help protect against it. By studying these responses, the lab aims to uncover potential therapeutic targets for preserving healthy insulin production in diabetic patients.
Type 1 diabetesbeta cellsenescencecell stress responsesimmune responsemolecular heterogeneityautoimmunityproteomicssingle-cell multiomicstherapeutic interventions
Research Aims
5AIM 01Define the molecular and epigenetic diversity of senescent beta cells in human islets.
AIM 02Analyze the progression and stability of different beta cell senescence programs over time.
AIM 03Identify the distinct senescence programs in beta cells that influence T1D outcomes.
AIM 04Explore publicly available datasets to assess beta cell senescence heterogeneity in T1D.
AIM 05Develop therapeutic strategies to enhance beneficial beta cell responses while minimizing detrimental effects.
Skills the Lab Values
cell culturesingle-cell sequencingproteomicsepigenetic analysismolecular profilinganimal modelsdata miningimmunological assaysbioinformaticsexperimental design
Output against the department
Publications32bottom 2% of dept.394th of 402
this lab
most publishedleast published
Citations2.6kbottom 12% of dept.352nd of 402
this lab
most citedleast cited
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