University of California-Irvine · NeuroscienceNeuroGuard Initiative
Daniela Annenelie Bota · Irvine, California
Research Focus
Dr. Daniela Bota's lab at UC Irvine focuses on understanding and alleviating the negative effects of chemotherapy on the nervous system, particularly for women with ovarian cancer. By targeting specific molecular pathways that lead to damage, the team aims to find ways to reduce cognitive decline and neuropathic pain that often accompany cisplatin treatment. Their research seeks to develop new treatments to improve patients' quality of life.
cisplatinchemotherapyneurotoxicityneuronal apoptosispain management
Research Aims
3AIM 01Investigate the role of p38/JNK signaling in cisplatin-induced neuronal damage.
AIM 02Test the effectiveness of inhibitors on reducing chemotherapy-related cognitive impairment and neuropathy.
AIM 03Evaluate the impact of cisplatin on gait changes and overall neurological function in mouse models.
Skills the Lab Values
in vitro experimentationpharmacological inhibitionmouse modelsbehavioral analysisRNA interference (siRNA)sensory testingcognitive assessmentneuroanatomy techniquesdata analysis in neuroscience
Output against the department
Publications322top 21% of dept.140th of 671
this lab
most publishedleast published
Citations8.0ktop 47% of dept.317th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.