Yale University · GeneticsJiang Genomics Lab
Yong-Hui Jiang · New Haven, Connecticut
Research Focus
Dr. Yong-Hui Jiang's lab at Yale University focuses on understanding genetic factors that contribute to recurrent pregnancy loss and developing new gene editing techniques to treat neurogenetic diseases. Their innovative research employs large-scale genomic studies to identify genetic predictors of pregnancy complications and explores non-viral CRISPR delivery systems to enable targeted therapies for conditions like Angelman syndrome. The lab also collaborates with a network that aims to accelerate the diagnosis of undiagnosed diseases through advanced genomic technologies.
genomicsrecurrent pregnancy lossCRISPRgene therapyneurodevelopmental diseasesbioinformaticsgenetic disordersundallergic diseases
Research Aims
5AIM 01Identify genetic variants associated with recurrent pregnancy loss through large-scale genomic studies.
AIM 02Develop and optimize non-viral CRISPR delivery systems for treating neurodevelopmental disorders.
AIM 03Increase understanding of the genetic basis for undiagnosed diseases using next-generation sequencing techniques.
AIM 04Analyze pathogenic variants to construct a human intolerome that sheds light on genetic causes of pregnancy complications.
AIM 05Collaborate with community partners to improve access to advanced diagnostic services for underrepresented groups.
Skills the Lab Values
whole genome sequencing (WGS)RNA sequencingbioinformatics analysisCRISPR gene editingmouse modelscell culturevariant detectiondata integration techniquesclinical study designmachine learning applications
Output against the department
Publications246top 34% of dept.89th of 259
this lab
most publishedleast published
Citations13ktop 41% of dept.107th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.