MCWMedical College of Wisconsin · Biology
Psychedelic Pharmacology and Design Lab
John D Mccorvy · Milwaukee, Wisconsin
Research Focus
Dr. John D Mccorvy's lab focuses on exploring the pharmacological potential of psychedelics, particularly their effects on mental health disorders like depression. By designing and developing new chemical probes specifically targeting serotonin receptors, the lab aims to differentiate between the therapeutic effects and the psychedelic experiences, paving the way for innovative treatments in psychiatry. Their research combines both structure-based drug design and an in-depth understanding of signaling pathways related to serotonin receptors.
psychedelicsserotonin receptorsdrug designmental healthbiased agonism
Research Aims
3AIM 01Develop selective serotonin receptor agonists as chemical probes.
AIM 02Investigate the relationship between receptor selectivity and therapeutic effects.
AIM 03Design biased agonists to differentiate psychedelic and antidepressant outcomes.
Skills the Lab Values
structural biologychemical synthesisreceptor binding assaysin vivo modelspharmacological profiling
Output against the department
Publications128bottom 46% of dept.558th of 1,033
this lab
most publishedleast published
Citations10ktop 37% of dept.385th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.