University of Rochester · BiologyEpigenome Dynamics and Aging Unit
Andrei Seluanov · Rochester, New York
Research Focus
Dr. Andrei Seluanov's lab at the University of Rochester focuses on understanding how the stability of the epigenome is regulated during aging, particularly through the action of the SIRT6 protein. The lab investigates the molecular mechanisms that underlie age-related declines in cell and organ function, leveraging techniques like mass spectrometry and genetic models to explore how SIRT6 influences DNA repair and longevity. Their work aims to discover new treatments for age-related diseases by revealing insights into the aging process.
epigenome stabilityagingSIRT6DNA repairlongevity
Research Aims
3AIM 01Examine the role of SIRT6 in maintaining epigenome stability during aging
AIM 02Investigate the biological function of SIRT6 target proteins like histones and chromatin remodelers
AIM 03Analyze the impact of SIRT6 mono-ADP ribosylation on longevity using a knock-in mouse model.
Skills the Lab Values
mass spectrometrymouse modelsDNA damage assaysChIP-seqcell culture
Output against the department
Publications240top 25% of dept.263rd of 1,033
this lab
most publishedleast published
Citations19ktop 20% of dept.211th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.