Icahn School of Medicine at Mount Sinai · BiologyZhe Regeneration Lab
Zhe Ying · New York, New York
Research Focus
Dr. Zhe Ying's lab at the Icahn School of Medicine focuses on the regeneration of salivary glands after they are damaged by radiation therapy. They are particularly interested in a gene called Smarca2, which plays a crucial role in the growth of salivary cells without promoting cancer growth. Their innovative research aims to develop techniques that can selectively enhance the recovery of salivary glands, which are vital for functions like swallowing and speaking, while minimizing the risk of cancer recurrence.
salivary glandscancer radiation therapySmarca2gene targetingchromatin remodelingcellular regenerationacinar cells
Research Aims
5AIM 01Develop a gene targeting system to test genetic conditions in salivary glands.
AIM 02Investigate the role of Smarca2 in promoting salivary epithelium growth post-irradiation.
AIM 03Explore chromatin remodeling mechanisms associated with acinar cell expansion.
AIM 04Identify genetic regulators that promote regeneration in salivary glands without affecting cancer cells.
AIM 05Establish distinct mechanisms of post-radiation growth control in salivary epithelium versus cancer.
Skills the Lab Values
gene targetingCRISPRATAC-seqChIP-seqcell culturemouse modelssmall hairpin RNAfluorescence microscopygenetic screening
Output against the department
Publications205top 32% of dept.330th of 1,033
this lab
most publishedleast published
Citations16ktop 24% of dept.253rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.