University of South Florida · BiochemistryBIN1 and Neuroinflammation Research Lab
Gopal Thinakaran · Tampa, Florida
Research Focus
Dr. Gopal Thinakaran's lab focuses on understanding the role of a protein called BIN1 in Alzheimer's disease. They study how BIN1 influences inflammation and the progression of neurodegenerative processes related to amyloid and tau proteins in the brain. The research involves using specific mouse models to investigate the mechanisms through which BIN1 impacts brain health and disease, with the ultimate goal of uncovering potential therapeutic targets for Alzheimer's.
Alzheimer's diseasemicrogliaBIN1tau pathologyneuroinflammation
Research Aims
3AIM 01Investigate the role of microglial BIN1 in amyloid-related pathology and neuroinflammation.
AIM 02Characterize tau pathology modulation by BIN1 in targeted brain regions using inducible knockout mice.
AIM 03Define the interactome of BIN1 in microglia to understand its role in immune signaling.
Skills the Lab Values
mouse modelsgene editingRNA sequencingtranscriptomicsmolecular biology techniques
Output against the department
Publications175top 49% of dept.196th of 402
this lab
most publishedleast published
Citations15ktop 30% of dept.121st of 402
this lab
most citedleast cited
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