Johns Hopkins University · PhysiologyPluznick Hypertension Lab
Jennifer L Pluznick · Baltimore, Maryland
Research Focus
Dr. Jennifer L. Pluznick's lab at Johns Hopkins University focuses on understanding how the olfactory receptor OLFR558 influences blood pressure differences between men and women. The lab explores sex differences in blood pressure regulation using various models, including knockout mice, and investigates the role of OLFR558 ligands—substances that activate this receptor. This research aims to reveal the underlying mechanisms of hypertension and potentially identify new therapeutic strategies.
blood pressuresex differencesolfactory receptorligandshypertensionkidneyvascular smooth musclemicrobiomeagonistsanimal models
Research Aims
3AIM 01Identify the cell types responsible for sex differences in blood pressure through OLFR558.
AIM 02Investigate the influence of gonadal signals on OLFR558's role in blood pressure regulation.
AIM 03Examine how OLFR558 contributes to hypertension in different models.
Skills the Lab Values
mouse modelsblood pressure telemetryligand binding assayscell culturerenal physiology experimentsgenotypingPCRimmunohistochemistryflow cytometrydata analysis in R
Output against the department
Publications164top 44% of dept.126th of 286
this lab
most publishedleast published
Citations6.0kbottom 47% of dept.151st of 286
this lab
most citedleast cited
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