University of California-San Francisco · PhysiologyTMEM16 Function and Disease Unit
Lily Jan · San Francisco, California
Research Focus
Dr. Lily Jan's lab at UCSF focuses on understanding a family of proteins known as TMEM16, which play crucial roles in how neurons communicate and regulate various physiological functions. Through techniques such as cryo-electron microscopy and site-directed mutagenesis, the lab investigates how these proteins function as ion channels and lipid scramblases, contributing to exciting areas like neurodegeneration and pain sensitivity. This research is essential for uncovering the mechanisms behind human diseases linked to these proteins.
TMEM16calcium-activated chloride channelsneural excitabilitylipid scramblasesneurodegenerationpain signalingion channelscry-electron microscopyknockout mice
Research Aims
5AIM 01Investigate the functions of TMEM16 family proteins in neuronal signaling.
AIM 02Elucidate the mechanisms of calcium-activated ion channels.
AIM 03Examine the role of TMEM16F in lipid scrambling and vesicle formation.
AIM 04Study the physiological functions of TMEM16 proteins in thermoregulation.
AIM 05Explore the relationship between TMEM16 proteins and human diseases.
Skills the Lab Values
Cryo-electron microscopySite-directed mutagenesisMolecular characterizationNeuronal cell cultureCRISPR gene editingFluorescent protein taggingAnimal models (mouse)Calcium imagingElectrophysiology
Output against the department
Publications598top 3% of dept.10th of 286
this lab
most publishedleast published
Citations81ktop 1% of dept.2nd of 286
this lab
most citedleast cited
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