Washington University in St Louis · NeuroscienceAlzheimer's Neurobiology Lab
John R Cirrito · Saint Louis, Missouri
Research Focus
Dr. John Cirrito's lab at Washington University focuses on understanding how synaptic activity in the brain impacts the formation and aggregation of amyloid-beta, a critical component involved in Alzheimer's disease. By using specialized technologies to monitor these processes in real-time, the lab aims to determine how different types of neurons contribute to amyloid-beta production and aggregation, potentially leading to new insights for developing therapies against Alzheimer's disease.
amyloid-betaAlzheimer's diseaseneuroscienceneuron activityreal-time monitoringneurodegenerationsynaptic regulationtoxicityneurobiology
Research Aims
3AIM 01Investigate how synaptic activity influences amyloid-beta aggregation into toxic oligomers.
AIM 02Identify whether excitatory or inhibitory neurons are primarily responsible for amyloid-beta production.
AIM 03Examine the effects of neuronal activity modulation on the development of amyloid plaques.
Skills the Lab Values
electrochemical measurementsmicro-immunoelectrode technologymouse modelsimmunofluorescencebiochemical assaysdata analysiscell culture techniquesin vivo imagingpatch clamp technique
Output against the department
Publications158top 47% of dept.314th of 671
this lab
most publishedleast published
Citations21ktop 19% of dept.129th of 671
this lab
most citedleast cited
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