University of California-San Francisco · PharmacologyT Cell Traffic Lab
Wendell A Lim · San Francisco, California
Research Focus
Dr. Wendell Lim's lab at UCSF focuses on engineering immune cells to improve their ability to infiltrate and effectively treat solid tumors that typically repel immune responses. By developing synthetic circuits that enhance T cell trafficking towards these tumors, the team aims to increase the effectiveness of CAR T cell therapies, particularly against immune-excluded tumors like pancreatic cancer. This innovative approach to immunotherapy has the potential to revolutionize cancer treatment by making even hard-to-treat tumors vulnerable to immune attack.
CAR T cellsimmunotherapytumor infiltrationsynthetic biologycancer treatmentpancreatic cancertraffic engineeringT cell therapyimmune response
Research Aims
3AIM 01Design synthetic circuits that enhance T cell chemotaxis, adhesion, and proliferation in response to tumor signals.
AIM 02Test synthetic trafficking circuits in laboratory models to assess their efficacy in promoting T cell infiltration.
AIM 03Evaluate the impact of engineered T cells on tumor clearance in immune-excluded pancreatic cancer models.
Skills the Lab Values
cell cultureCRISPRin vivo mouse modelsin vitro tissue modelingcomputational modelingflow cytometrysingle cell analysissynthetic circuit designmicrofabrication techniques
Output against the department
Publications267top 30% of dept.139th of 462
this lab
most publishedleast published
Citations45ktop 6% of dept.26th of 462
this lab
most citedleast cited
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