University of Colorado Boulder · ChemistryTaatjes Transcription Lab
Dylan J Taatjes · Boulder, Colorado
Research Focus
Dr. Dylan Taatjes' lab at the University of Colorado focuses on understanding how RNA polymerase II, an essential enzyme that helps transcribe DNA into RNA, is regulated during the process of gene expression. The lab combines biochemical experiments and advanced cellular assays to investigate the mechanisms that control RNA polymerase II activity, which is critical for normal cell function and can lead to diseases like cancer and neurological disorders when disrupted.
RNA polymerase IItranscription regulationgene expressionbiochemical reconstitutiontranscription factors
Research Aims
3AIM 01Investigate how RNAPII activity is controlled at gene promoters.
AIM 02Explore the role of condensates in activating RNAPII transcription.
AIM 03Dissect the mechanisms by which enhancers regulate RNAPII activity.
Skills the Lab Values
PCRcell culturebiochemical assaysRNA sequencingmicroscopy
Output against the department
Publications130bottom 30% of dept.152nd of 216
this lab
most publishedleast published
Citations15ktop 32% of dept.70th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.