University of California-Irvine · BiochemistryMasri Oncology Lab
Selma Masri · Irvine, California
Research Focus
Dr. Selma Masri's research lab focuses on understanding how disruptions in our body's internal clock, known as the circadian clock, can influence the development of colorectal cancer, particularly in younger adults. The lab investigates how these disruptions impact cellular changes in the intestine, metabolism, and immune responses that may contribute to cancer progression. Through innovative mouse models and patient-derived samples, the lab aims to identify new prevention and treatment strategies for colorectal cancer.
circadian clockcolorectal cancercellular metabolismimmune regulationearly-onset cancersdietary factorstumorigenesisgenetic mouse models
Research Aims
3AIM 01Define how the circadian clock regulates genome instability in intestinal cells.
AIM 02Investigate the role of the circadian clock on metabolism in colorectal cancer.
AIM 03Examine how dietary disruptions of the circadian clock affect cancer progression.
Skills the Lab Values
mouse modelsorganoid culturescellular transformation assaysmetabolic profilingimmunohistochemistrygene expression analysisdiet manipulation studiesdata analysis using softwareWestern blotPCR
Output against the department
Publications99bottom 24% of dept.304th of 402
this lab
most publishedleast published
Citations4.3kbottom 24% of dept.306th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.