Columbia University in the City of New York · Biomedical EngineeringThe Bacterial OncoTherapy Lab
Tal Danino · New York, New York
Research Focus
Tal Danino's research lab focuses on developing innovative bacterial therapies to enhance cancer treatments, particularly for triple-negative breast cancer. By engineering probiotic bacteria to deliver therapeutics directly to tumors, the lab aims to overcome the limitations of traditional immunotherapy, offering safer and more effective options for patients. They utilize advanced synthetic biology techniques to create systems that allow these bacteria to selectively release drugs at the tumor site.
cancer immunotherapyprobiotic bacteriagene editingsynthetic biologytumor targeting
Research Aims
3AIM 01Engineer probiotic bacteria to selectively colonize tumors.
AIM 02Develop encapsulation systems for improved drug delivery.
AIM 03Test bacterial strains for safety and efficacy in tumor environments.
Skills the Lab Values
bacterial culturegenetic engineeringsynthetic biologyin vitro assaysmouse models
Output against the department
Publications106bottom 19% of dept.481st of 595
this lab
most publishedleast published
Citations9.4ktop 37% of dept.219th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.