UWMUniversity of Wisconsin-Madison · Chemistry
Proteoform Discovery Lab
Lloyd M Smith · Madison, Wisconsin
Research Focus
The Smith Lab at the University Of Wisconsin-Madison focuses on innovative approaches to proteomics, specifically targeting 'proteoforms,' which are unique protein variants shaped by specific amino acid sequences and modifications. Their research aims to identify and analyze these proteoforms in complex biological systems, providing insights into how they influence cell functions and responses related to health and disease. By developing advanced tools and methods, the lab contributes to a broader understanding of cellular mechanisms and supports the scientific community's efforts to address health challenges.
proteomicsproteoformspost-translational modificationsbioinformaticsmass spectrometrysystems biologyhuman diseasequantitative trait locicomputational tools
Research Aims
5AIM 01Develop new tools for comprehensive proteoform analysis.
AIM 02Create advanced bioinformatic frameworks for proteomic data interpretation.
AIM 03Identify mechanisms of cellular response to post-translational modifications.
AIM 04Reveal new insights into normal and disease biology.
AIM 05Collaborate on the Human Proteoform Project to enhance global proteomic knowledge.
Skills the Lab Values
mass spectrometryproteomic analysisbioinformatics softwaredata visualizationRNA sequencingpost-translational modification analysismulti-dimensional separation techniquesreal-time data acquisitionalgorithm development
Output against the department
Publications507top 17% of dept.37th of 216
this lab
most publishedleast published
Citations31ktop 14% of dept.30th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.