University of North Texas Health Science Center · PharmacologyThe Hormone Health Lab
Rebecca L Cunningham · Fort Worth, Texas
Research Focus
Dr. Rebecca Cunningham's lab focuses on understanding why women are at a higher risk for Alzheimer's disease compared to men, especially after menopause. They investigate how sex hormones and specific genes influence brain health, particularly examining the role of a hormone called angiotensin II in Alzheimer's pathology. Through their research, they aim to uncover new insights that could lead to better prevention and treatment strategies for this disease in women.
Alzheimer's Diseasesex differencesangiotensin IIhormone replacement therapyoxidative stresscognitive impairmentneurobiologyagingsex hormones
Research Aims
3AIM 01Investigate how circulating hormones affect brain angiotensin II levels and cognitive decline.
AIM 02Examine the impact of brain-derived hormones on angiotensin II-related oxidative stress.
AIM 03Assess the independent effects of sex hormones and sex chromosomes on cognitive impairment and Alzheimer's pathogenesis.
Skills the Lab Values
rodent modelshormone assaysbiochemical analysisbehavioral testing in ratsstatistical analysisdata interpretationimmunohistochemistrygene expression techniquesneuroanatomical techniques
Output against the department
Publications118bottom 33% of dept.308th of 462
this lab
most publishedleast published
Citations2.1kbottom 14% of dept.396th of 462
this lab
most citedleast cited
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