Ohio State University-Main Campus · GeneticsLab of Biological Oscillators and Developmental Dynamics
Sharon L Amacher · Columbus, Ohio
Research Focus
Dr. Sharon Amacher's lab at Ohio State University focuses on understanding how rhythmic patterns of gene expression, known as biological oscillators, regulate important developmental processes. Their research explores these oscillators' roles in processes like organ development and cellular differentiation, especially during the formation of somites, which are essential for building vertebrate body structures. By studying various model organisms, they aim to uncover the genetic and molecular mechanisms behind these oscillatory patterns, contributing to our knowledge of developmental biology and stem cell regulation.
developmental regulationbiological oscillatorssomitogenesisgene expressionpost-transcriptional regulationmolecular dynamicsArabidopsisC. eleganscircadian rhythmsstem cell maintenance
Research Aims
5AIM 01Investigate the roles of core Hes/Her oscillators in regulating oscillatory gene expression.
AIM 02Identify targets of oscillators that influence the segmentation clock.
AIM 03Explore post-transcriptional mechanisms that control gene transcript decay.
AIM 04Analyze the timing of mRNA processing in developmental contexts.
AIM 05Model the effects of transcription and translation delays on gene oscillations.
Skills the Lab Values
mRNA extractionPCRgene editingcomputational modelingcell culturegenetic analysisreporter gene assaysprotein quantificationin vivo imagingtranscriptional analysis
Output against the department
Publications96bottom 30% of dept.181st of 259
this lab
most publishedleast published
Citations5.7kbottom 31% of dept.178th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.