Duke University · BiologyLung Regeneration Lab
Purushothama Rao Tata · Durham, North Carolina
Research Focus
Dr. Purushothama Rao Tata's lab at Duke University studies how cells in the lungs communicate and repair themselves after injury, focusing on understanding lung diseases like pulmonary fibrosis. The research explores how balance in cellular responses and specific molecular signals can influence the healing process in lung tissue. By uncovering these mechanisms, the lab aims to identify potential new treatments to enhance lung repair and improve patient outcomes.
alveolar regenerationpulmonary fibrosiscell communicationoxidative stresslung injurycell plasticityfibroblast identitytranscription factorscell signaling
Research Aims
3AIM 01Investigate the role of oxidative stress in alveolar epithelial cell quiescence and plasticity.
AIM 02Examine the genetic interactions between GPX4, NRF2, and TP53 in alveolar epithelial repair.
AIM 03Analyze the dynamics of oxidative stress in normal and aberrant epithelial cells in human lungs.
Skills the Lab Values
genetic mouse modelspharmacological interventionsPCRcell cultureWestern blotRNA sequencingsingle-cell transcriptomicsmicroscopybioinformatics
Output against the department
Publications118bottom 42% of dept.595th of 1,033
this lab
most publishedleast published
Citations14ktop 27% of dept.280th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.