University of California-San Francisco · NeuroscienceNeurodegenerative Disease Research Lab
William W Seeley · San Francisco, California
Research Focus
Dr. William W. Seeley's lab at UCSF focuses on understanding the causes of frontotemporal dementia and motor neuron disease, two worsening neurodegenerative disorders. They investigate the role of certain proteins, like TDP-43, that misbehave in these conditions. By studying brain samples, they aim to find new insights that could lead to better treatments for these challenging diseases.
frontotemporal dementiamotor neuron diseaseTDP-43neurodegenerationpathogenesis
Research Aims
3AIM 01Investigate the relationship between C9orf72-associated proteins and TDP-43 in frontotemporal dementia.
AIM 02Characterize features of TDP-43 inclusions in sporadic cases of motor neuron disease.
AIM 03Identify novel protein interactions that might contribute to disease progression in diverse cohorts of patients.
Skills the Lab Values
multiplexed immunofluorescencebiochemical methodsproteomicshistological analysisco-immunoprecipitations
Output against the department
Publications658top 8% of dept.52nd of 671
this lab
most publishedleast published
Citations76ktop 3% of dept.23rd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.