University of Michigan-Ann Arbor · Mathematics & StatisticsParker Diabetes Lab
Stephen Cj Parker · Ann Arbor, Michigan
Research Focus
Dr. Stephen Cj Parker's lab focuses on understanding how genetic and environmental factors contribute to diabetes, particularly type 2 diabetes (T2D). They use advanced technologies to study the molecular mechanisms behind insulin resistance, examining various cell types within the pancreas to uncover how genetic variations can impact disease development and tissue organization. The lab aims to create more precise predictions and therapeutic strategies for diabetes by mapping the complex regulatory networks involved.
diabetesgeneticsmulti-omicsinsulin resistancepancreasGWAStranscriptional regulationcell typesenvironmental factorsepigenomics
Research Aims
5AIM 01Identify causal genetic variants and their target genes related to diabetes.
AIM 02Profile multi-omic data from pancreatic tissues to understand genetic regulation.
AIM 03Map diabetes-related genetic signals across different cell types and contexts.
AIM 04Investigate the role of macrophages in pancreatic cell function and pathology.
AIM 05Develop integrative tools for analyzing complex relationships in diabetes research.
Skills the Lab Values
RNA sequencingsingle-cell genomicsmulti-omics analysischromatin analysisdata integrationbioinformaticsmachine learninggenotype-phenotype associationfunctional genomicsreporter assays
Output against the department
Publications228top 49% of dept.64th of 131
this lab
most publishedleast published
Citations16ktop 27% of dept.36th of 131
this lab
most citedleast cited
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