University of Michigan-Ann Arbor · BiochemistryHIV Trafficking and Mechanisms Lab
Michael Cianfrocco · Ann Arbor, Michigan
Research Focus
Michael Cianfrocco's lab at the University of Michigan focuses on understanding how the HIV-1 virus navigates within host cells. Their research aims to uncover the molecular mechanisms that allow HIV-1 to exploit cellular transport systems, particularly the dynein motor proteins, to reach the nucleus of the infected cell. By investigating these interactions, the lab hopes to identify new therapeutic targets to prevent HIV-1 infection and improve treatment options.
HIV-1viral traffickingdyneinmotor proteinscell nucleusmicrotubulescryo-electron microscopyprotein interactionshost-pathogen interaction
Research Aims
3AIM 01Determine how HIV-1 recruits and activates dynein for retrograde motility.
AIM 02Characterize the binding sites of dynein on the HIV-1 capsid using cryo-EM.
AIM 03Identify cargo adaptors that HIV-1 exploits in different cell types.
Skills the Lab Values
single-molecule fluorescence microscopycryo-electron tomographybiochemical assaysviral reconstitution techniquescell culturemolecular cloningprotein purificationfluorescence imagingdata analysis in microscopy
Output against the department
Publications162bottom 46% of dept.218th of 402
this lab
most publishedleast published
Citations2.3kbottom 8% of dept.369th of 402
this lab
most citedleast cited
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