Icahn School of Medicine at Mount Sinai · PharmacologyCellular Transport and pH Regulation Lab
Daniel Wacker · New York, New York
Research Focus
Dr. Daniel Wacker's research lab explores cellular transporters in the brain that regulate the pH balance, crucial for maintaining proper neuronal function. The lab focuses on understanding the structure and function of specific bicarbonate transporters linked to neurological disorders, aiming to develop tools for drug discovery that could lead to new treatments. By combining various scientific techniques, the lab seeks to uncover the molecular mechanisms behind these transporters and their potential therapeutic applications.
SLC4 transportersneuronal signalingdrug discoverycellular pH regulationneurological disorders
Research Aims
3AIM 01Elucidate the substrate stoichiometries of SLC4A7, SLC4A8, and SLC4A10.
AIM 02Develop subtype-selective SLC4 tool compounds via computational drug discovery.
AIM 03Validate the utility of novel probes in primary neuronal culture and human-derived neurons.
Skills the Lab Values
cryoelectron microscopymolecular dynamics simulationselectrophysiologycell culturestructure-based drug design
Output against the department
Publications80bottom 18% of dept.378th of 462
this lab
most publishedleast published
Citations8.6ktop 43% of dept.199th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.