Washington University in St Louis · Biomedical EngineeringMarkovina Lab
Stephanie Markovina · Saint Louis, Missouri
Research Focus
Dr. Stephanie Markovina's lab focuses on improving treatment outcomes for cervical cancer, which remains a significant health challenge. By studying the role of a protein called SERPINB3, the lab aims to understand how certain tumor cells become resistant to radiation and chemotherapy and to develop new treatment strategies. Their research combines laboratory techniques with clinical trials to offer more effective, personalized treatment options for patients.
cervical cancerSERPINB3radiation therapychemotherapyimmunotherapytumor microenvironmentlysosomal membrane permeabilizationtumor resistancepreclinical modelsbiomarkers
Research Aims
3AIM 01Investigate the cell death mechanism induced by radiation in SERPINB3-high tumors.
AIM 02Determine how therapy induces lysosomal membrane permeabilization leading to cell death.
AIM 03Identify strategies to target SERPINB3 in tumor cells to enhance sensitivity to radiation therapy.
Skills the Lab Values
CRISPR-Cas9cell culturein vivo modelsorganelles isolationimmunohistochemistryflow cytometrydata analysisPCRbiomedical imaging technologyanimal handling
Output against the department
Publications146bottom 31% of dept.407th of 595
this lab
most publishedleast published
Citations2.0kbottom 13% of dept.515th of 595
this lab
most citedleast cited
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